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Irritable bowel syndrome

MedGen UID:
5897
•Concept ID:
C0022104
•
Disease or Syndrome
Synonyms: Colitides, Mucous; Colitis, Mucous; Colon, Irritable; Irritable Bowel Syndrome; Irritable Bowel Syndromes; Irritable Colon; Mucous Colitides; Mucous Colitis; Syndrome, Irritable Bowel; Syndromes, Irritable Bowel
SNOMED CT: Colon spasm (10743008); Functional bowel disease (10743008); Nervous colitis (10743008); IBS - Irritable bowel syndrome (10743008); Irritable bowel (10743008); Spastic colitis (10743008); Irritable colon syndrome (10743008); IC - Irritable colon (10743008); Irritable colon (10743008); Adaptive colitis (10743008); Membranous colitis (10743008); Spastic colon (10743008); Irritable bowel syndrome (10743008); Mucous colitis (10743008)
 
Monarch Initiative: MONDO:0005052

Definition

Gastrointestinal symptoms characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIrritable bowel syndrome

Professional guidelines

PubMed

Diagnosis and Treatment of Irritable Bowel Syndrome: A Review.
Camilleri M
JAMA 2021 Mar 2;325(9):865-877. doi: 10.1001/jama.2020.22532. PMID: 33651094
ACG Clinical Guideline: Management of Irritable Bowel Syndrome.
Lacy BE, Pimentel M, Brenner DM, Chey WD, Keefer LA, Long MD, Moshiree B
Am J Gastroenterol 2021 Jan 1;116(1):17-44. doi: 10.14309/ajg.0000000000001036. PMID: 33315591
Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine.
Saha L
World J Gastroenterol 2014 Jun 14;20(22):6759-73. doi: 10.3748/wjg.v20.i22.6759. PMID: 24944467Free PMC Article

Recent clinical studies

Etiology

Diet, fibers, and probiotics for irritable bowel syndrome.
Galica AN, Galica R, Dumitrașcu DL
J Med Life 2022 Feb;15(2):174-179. doi: 10.25122/jml-2022-0028. PMID: 35419092Free PMC Article
Irritable bowel syndrome.
Sebastián Domingo JJ
Med Clin (Barc) 2022 Jan 21;158(2):76-81. Epub 2021 Jul 6 doi: 10.1016/j.medcli.2021.04.029. PMID: 34238582
Irritable bowel syndrome.
Ford AC, Sperber AD, Corsetti M, Camilleri M
Lancet 2020 Nov 21;396(10263):1675-1688. Epub 2020 Oct 10 doi: 10.1016/S0140-6736(20)31548-8. PMID: 33049223
Irritable bowel syndrome.
Enck P, Aziz Q, Barbara G, Farmer AD, Fukudo S, Mayer EA, Niesler B, Quigley EM, Rajilić-Stojanović M, Schemann M, Schwille-Kiuntke J, Simren M, Zipfel S, Spiller RC
Nat Rev Dis Primers 2016 Mar 24;2:16014. doi: 10.1038/nrdp.2016.14. PMID: 27159638Free PMC Article
Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine.
Saha L
World J Gastroenterol 2014 Jun 14;20(22):6759-73. doi: 10.3748/wjg.v20.i22.6759. PMID: 24944467Free PMC Article

Diagnosis

Irritable bowel syndrome: Epidemiology, overlap disorders, pathophysiology and treatment.
Huang KY, Wang FY, Lv M, Ma XX, Tang XD, Lv L
World J Gastroenterol 2023 Jul 14;29(26):4120-4135. doi: 10.3748/wjg.v29.i26.4120. PMID: 37475846Free PMC Article
Irritable bowel syndrome.
Sebastián Domingo JJ
Med Clin (Barc) 2022 Jan 21;158(2):76-81. Epub 2021 Jul 6 doi: 10.1016/j.medcli.2021.04.029. PMID: 34238582
Irritable Bowel Syndrome: Epidemiology, Pathophysiology, Diagnosis, and Treatment.
Defrees DN, Bailey J
Prim Care 2017 Dec;44(4):655-671. Epub 2017 Oct 5 doi: 10.1016/j.pop.2017.07.009. PMID: 29132527
Irritable bowel syndrome: a clinical review.
Chey WD, Kurlander J, Eswaran S
JAMA 2015 Mar 3;313(9):949-58. doi: 10.1001/jama.2015.0954. PMID: 25734736
Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine.
Saha L
World J Gastroenterol 2014 Jun 14;20(22):6759-73. doi: 10.3748/wjg.v20.i22.6759. PMID: 24944467Free PMC Article

Therapy

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome.
Vasant DH, Paine PA, Black CJ, Houghton LA, Everitt HA, Corsetti M, Agrawal A, Aziz I, Farmer AD, Eugenicos MP, Moss-Morris R, Yiannakou Y, Ford AC
Gut 2021 Jul;70(7):1214-1240. Epub 2021 Apr 26 doi: 10.1136/gutjnl-2021-324598. PMID: 33903147
Efficacy of psychological therapies for irritable bowel syndrome: systematic review and network meta-analysis.
Black CJ, Thakur ER, Houghton LA, Quigley EMM, Moayyedi P, Ford AC
Gut 2020 Aug;69(8):1441-1451. Epub 2020 Apr 10 doi: 10.1136/gutjnl-2020-321191. PMID: 32276950
Bacillus coagulans and its applications in medicine.
Mu Y, Cong Y
Benef Microbes 2019 Jul 10;10(6):679-688. Epub 2019 Jun 17 doi: 10.3920/BM2019.0016. PMID: 31203635
Clinical Application and Potential of Fecal Microbiota Transplantation.
Ooijevaar RE, Terveer EM, Verspaget HW, Kuijper EJ, Keller JJ
Annu Rev Med 2019 Jan 27;70:335-351. Epub 2018 Nov 7 doi: 10.1146/annurev-med-111717-122956. PMID: 30403550
The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS.
Staudacher HM, Whelan K
Gut 2017 Aug;66(8):1517-1527. Epub 2017 Jun 7 doi: 10.1136/gutjnl-2017-313750. PMID: 28592442

Prognosis

Ultra-Processed Food Consumption and Long-Term Risk of Irritable Bowel Syndrome: A Large-Scale Prospective Cohort Study.
Wu S, Yang Z, Liu S, Zhang Q, Zhang S, Zhu S
Clin Gastroenterol Hepatol 2024 Jul;22(7):1497-1507.e5. Epub 2024 Mar 21 doi: 10.1016/j.cgh.2024.01.040. PMID: 38522476
Endometriosis and irritable bowel syndrome: a systematic review and meta-analysis.
Chiaffarino F, Cipriani S, Ricci E, Mauri PA, Esposito G, Barretta M, Vercellini P, Parazzini F
Arch Gynecol Obstet 2021 Jan;303(1):17-25. Epub 2020 Sep 19 doi: 10.1007/s00404-020-05797-8. PMID: 32949284
Clinical and Microbiological Effect of a Multispecies Probiotic Supplementation in Celiac Patients With Persistent IBS-type Symptoms: A Randomized, Double-Blind, Placebo-controlled, Multicenter Trial.
Francavilla R, Piccolo M, Francavilla A, Polimeno L, Semeraro F, Cristofori F, Castellaneta S, Barone M, Indrio F, Gobbetti M, De Angelis M
J Clin Gastroenterol 2019 Mar;53(3):e117-e125. doi: 10.1097/MCG.0000000000001023. PMID: 29688915Free PMC Article
Functional Dyspepsia and Irritable Bowel Syndrome: Beyond Rome IV.
Stanghellini V
Dig Dis 2017;35 Suppl 1:14-17. Epub 2018 Feb 8 doi: 10.1159/000485408. PMID: 29421792
Epidemiology of IBS.
Choung RS, Locke GR 3rd
Gastroenterol Clin North Am 2011 Mar;40(1):1-10. doi: 10.1016/j.gtc.2010.12.006. PMID: 21333897

Clinical prediction guides

Low FODMAP diet reduces gastrointestinal symptoms in irritable bowel syndrome and clinical response could be predicted by symptom severity: A randomized crossover trial.
Algera JP, Demir D, Törnblom H, Nybacka S, Simrén M, Störsrud S
Clin Nutr 2022 Dec;41(12):2792-2800. Epub 2022 Nov 4 doi: 10.1016/j.clnu.2022.11.001. PMID: 36384081
Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome.
Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, Verne GN
Gut 2019 Jun;68(6):996-1002. Epub 2018 Aug 14 doi: 10.1136/gutjnl-2017-315136. PMID: 30108163Free PMC Article
Lactose Intolerance in Adults: Biological Mechanism and Dietary Management.
Deng Y, Misselwitz B, Dai N, Fox M
Nutrients 2015 Sep 18;7(9):8020-35. doi: 10.3390/nu7095380. PMID: 26393648Free PMC Article
Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis.
Didari T, Mozaffari S, Nikfar S, Abdollahi M
World J Gastroenterol 2015 Mar 14;21(10):3072-84. doi: 10.3748/wjg.v21.i10.3072. PMID: 25780308Free PMC Article
The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress.
Francis CY, Morris J, Whorwell PJ
Aliment Pharmacol Ther 1997 Apr;11(2):395-402. doi: 10.1046/j.1365-2036.1997.142318000.x. PMID: 9146781

Recent systematic reviews

Efficacy of Probiotics for Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.
Zhang T, Zhang C, Zhang J, Sun F, Duan L
Front Cell Infect Microbiol 2022;12:859967. Epub 2022 Apr 1 doi: 10.3389/fcimb.2022.859967. PMID: 35433498Free PMC Article
Efficacy of a low FODMAP diet in irritable bowel syndrome: systematic review and network meta-analysis.
Black CJ, Staudacher HM, Ford AC
Gut 2022 Jun;71(6):1117-1126. Epub 2021 Aug 10 doi: 10.1136/gutjnl-2021-325214. PMID: 34376515
Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis.
van Lanen AS, de Bree A, Greyling A
Eur J Nutr 2021 Sep;60(6):3505-3522. Epub 2021 Feb 14 doi: 10.1007/s00394-020-02473-0. PMID: 33585949Free PMC Article
Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis.
Oka P, Parr H, Barberio B, Black CJ, Savarino EV, Ford AC
Lancet Gastroenterol Hepatol 2020 Oct;5(10):908-917. Epub 2020 Jul 20 doi: 10.1016/S2468-1253(20)30217-X. PMID: 32702295
Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review.
Dale HF, Rasmussen SH, Asiller ÖÖ, Lied GA
Nutrients 2019 Sep 2;11(9) doi: 10.3390/nu11092048. PMID: 31480656Free PMC Article

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